Setting description

Equal randomization: Carboplatin and Niraparib more effective in the DRD+ biomarker signature (cfr scen 6)

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66
DRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.037, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 26.6, median = 19.1
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 3.03, hr = 0.31
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.075, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 13.1, median = 9.4
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1.49, hr = 0.66

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 2 13 19
TP53- & AR- 12 12 140 119
TP53+ 1 1 25 17
DRD+ 0 0 291 301
TEfus+ 0 0 18 19
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.004 0.026 0.038
TP53- & AR- 0.024 0.024 0.280 0.238
TP53+ 0.002 0.002 0.050 0.034
DRD+ 0.000 0.000 0.582 0.602
TEfus+ 0.000 0.000 0.036 0.038
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 6 7 0 0
TP53- & AR- 247 233 22 18
TP53+ 74 74 3 2
DRD+ 214 197 0 0
TEfus+ 65 67 0 1
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.012 0.014 0.000 0.000
TP53- & AR- 0.494 0.466 0.044 0.036
TP53+ 0.148 0.148 0.006 0.004
DRD+ 0.428 0.394 0.000 0.000
TEfus+ 0.130 0.134 0.000 0.002
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 16 12 18 14
TP53+ 1 6 8 12
DRD+ 0 0 0 0
TEfus+ 0 0 0 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.032 0.024 0.036 0.028
TP53+ 0.002 0.012 0.016 0.024
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.000 0.000 0.000


Errors & power

The overall error was 0.268.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.026             0.030             0.134             0.106 

The overall power was 0.832.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.000             0.000             0.582             0.602 

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 0 2 13 19
futility 0 6 7 0 0
max_n 0 0 0 0 0
n 280 (245, 324) 208 (148, 275) 213 (144, 282) 232 (159, 287) 231 (171, 286)
n_unique 257 (224, 296) 194 (136, 257) 198 (134, 262) 214 (145, 265) 213 (155, 262)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 22 (15, 30) 27 (5, 34) 10 (4, 33) 27 (12, 34)
post_p NA (NA, NA) 0.4 (0.07, 0.86) 0.43 (0.07, 0.84) 1 (0.95, 1) 1 (0.93, 1)
rate 0.111 (0.102, 0.122) 0.113 (0.102, 0.126) 0.113 (0.103, 0.126) 0.082 (0.073, 0.091) 0.081 (0.072, 0.092)
TP53- & AR- graduation 0 12 12 140 119
futility 0 247 233 22 18
max_n 0 16 12 18 14
n 120 (95, 149) 82 (27, 122) 83 (27, 123) 96 (29, 130) 96 (32, 129)
n_unique 111 (87, 139) 75 (25, 114) 78 (26, 116) 89 (27, 122) 89 (29, 120)
time_trial 36 (36, 36) 32 (11, 36) 36 (11, 36) 36 (12, 36) 36 (13, 36)
time_stop NA (NA, NA) 15 (9, 30) 14 (10, 28) 15 (10, 32) 15 (10, 29)
post_p NA (NA, NA) 0.38 (0.08, 0.83) 0.39 (0.07, 0.85) 0.95 (0.67, 1) 0.94 (0.61, 1)
rate 0.111 (0.098, 0.129) 0.115 (0.098, 0.143) 0.114 (0.097, 0.144) 0.084 (0.068, 0.101) 0.084 (0.069, 0.102)
TP53+ graduation 0 1 1 25 17
futility 0 74 74 3 2
max_n 0 1 6 8 12
n 119 (102, 142) 105 (64, 125) 104 (68, 129) 104 (80, 127) 105 (80, 129)
n_unique 109 (92, 130) 97 (59, 115) 96 (63, 119) 95 (73, 117) 97 (74, 118)
time_trial 36 (36, 36) 36 (24, 36) 36 (27, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 18 (8, 32) 19 (9, 33) 12 (8, 23) 18 (10, 32)
post_p NA (NA, NA) 0.41 (0.08, 0.83) 0.42 (0.07, 0.8) 0.96 (0.66, 1) 0.96 (0.75, 1)
rate 0.111 (0.098, 0.129) 0.113 (0.098, 0.133) 0.114 (0.1, 0.133) 0.084 (0.07, 0.099) 0.082 (0.07, 0.097)
DRD+ graduation 0 0 0 291 301
futility 0 214 197 0 0
max_n 0 0 0 0 0
n 84 (67, 105) 56 (28, 88) 59 (30, 91) 59 (26, 88) 56 (27, 87)
n_unique 78 (61, 98) 51 (25, 80) 54 (28, 85) 53 (24, 81) 52 (25, 79)
time_trial 36 (36, 36) 36 (17, 36) 36 (19, 36) 33 (15, 36) 32 (16, 36)
time_stop NA (NA, NA) 21 (14, 32) 22 (16, 32) 24 (14, 34) 23 (14, 33)
post_p NA (NA, NA) 0.28 (0.05, 0.72) 0.26 (0.05, 0.72) 1 (1, 1) 1 (1, 1)
rate 0.112 (0.095, 0.131) 0.113 (0.094, 0.145) 0.114 (0.095, 0.139) 0.036 (0.028, 0.046) 0.036 (0.028, 0.045)
TEfus+ graduation 0 0 0 18 19
futility 0 65 67 0 1
max_n 0 0 0 0 0
n 104 (86, 125) 79 (49, 104) 80 (48, 109) 86 (58, 108) 83 (60, 108)
n_unique 95 (79, 113) 72 (44, 97) 74 (43, 100) 78 (52, 99) 76 (54, 98)
time_trial 36 (36, 36) 36 (29, 36) 36 (28, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 21 (12, 34) 22 (13, 31) 12 (10, 20) 18 (11, 30)
post_p NA (NA, NA) 0.43 (0.06, 0.82) 0.38 (0.07, 0.82) 0.98 (0.8, 1) 0.99 (0.86, 1)
rate 0.112 (0.096, 0.127) 0.113 (0.096, 0.135) 0.113 (0.097, 0.132) 0.074 (0.062, 0.091) 0.073 (0.06, 0.087)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 259 248 170 144
futility 0 0 0 0 0
max_n 0 16 12 18 14
n 73 (56, 94) 52 (17, 76) 52 (17, 77) 61 (20, 84) 63 (20, 83)
n_unique 67 (51, 88) 48 (16, 72) 50 (16, 73) 57 (18, 80) 58 (19, 79)
post_p NA (NA, NA) 0.46 (0.09, 0.84) 0.46 (0.1, 0.86) 0.52 (0.14, 0.89) 0.51 (0.11, 0.89)
rate 0.112 (0.094, 0.133) 0.116 (0.095, 0.147) 0.113 (0.094, 0.149) 0.112 (0.089, 0.135) 0.112 (0.092, 0.135)
—+ graduation 0 280 261 181 151
futility 0 0 0 0 0
max_n 0 16 12 18 14
n 15 (9, 22) 9 (3, 17) 9 (3, 18) 12 (3, 19) 12 (4, 20)
n_unique 14 (8, 20) 8 (2, 16) 8 (3, 17) 11 (3, 17) 11 (3, 18)
post_p NA (NA, NA) 0.44 (0.2, 0.83) 0.47 (0.19, 0.81) 0.49 (0.16, 0.81) 0.5 (0.17, 0.81)
rate 0.112 (0.077, 0.161) 0.119 (0.074, 0.214) 0.12 (0.075, 0.211) 0.117 (0.072, 0.185) 0.114 (0.074, 0.178)
–+- graduation 0 75 77 39 37
futility 0 0 0 0 0
max_n 0 1 6 8 12
n 37 (29, 47) 34 (21, 43) 35 (23, 44) 36 (24, 44) 36 (27, 45)
n_unique 34 (26, 44) 32 (20, 40) 32 (22, 41) 33 (22, 41) 33 (25, 42)
post_p NA (NA, NA) 0.48 (0.14, 0.88) 0.48 (0.14, 0.82) 0.48 (0.13, 0.85) 0.51 (0.14, 0.89)
rate 0.112 (0.09, 0.141) 0.113 (0.088, 0.148) 0.115 (0.092, 0.147) 0.114 (0.09, 0.144) 0.113 (0.088, 0.145)
–++ graduation 0 112 122 51 49
futility 0 0 0 0 0
max_n 0 1 6 8 12
n 25 (19, 34) 23 (11, 31) 23 (11, 30) 24 (14, 33) 24 (16, 32)
n_unique 23 (17, 31) 21 (10, 29) 21 (10, 29) 22 (13, 30) 22 (14, 29)
post_p NA (NA, NA) 0.48 (0.17, 0.87) 0.48 (0.16, 0.83) 0.5 (0.14, 0.83) 0.52 (0.18, 0.86)
rate 0.113 (0.085, 0.149) 0.114 (0.084, 0.159) 0.116 (0.085, 0.158) 0.113 (0.083, 0.153) 0.111 (0.084, 0.146)
-+– graduation 0 345 336 357 359
futility 0 0 0 0 0
max_n 0 16 12 16 12
n 16 (10, 23) 8 (3, 19) 8 (3, 18) 9 (3, 19) 10 (3, 18)
n_unique 14 (9, 22) 7 (2, 18) 8 (2, 17) 9 (3, 17) 9 (3, 16)
post_p NA (NA, NA) 0.3 (0.09, 0.59) 0.31 (0.1, 0.61) 0.92 (0.69, 0.99) 0.92 (0.63, 1)
rate 0.11 (0.08, 0.163) 0.12 (0.078, 0.216) 0.119 (0.077, 0.204) 0.036 (0.016, 0.065) 0.037 (0.018, 0.066)
-+-+ graduation 0 352 340 362 362
futility 0 0 0 0 0
max_n 0 16 12 16 12
n 16 (10, 23) 8 (3, 18) 8 (3, 18) 10 (3, 19) 9 (3, 18)
n_unique 15 (8, 21) 7 (2, 16) 7 (2, 17) 9 (2, 18) 8 (3, 17)
post_p NA (NA, NA) 0.32 (0.12, 0.61) 0.31 (0.1, 0.62) 0.92 (0.67, 0.99) 0.92 (0.66, 0.99)
rate 0.113 (0.074, 0.168) 0.117 (0.075, 0.215) 0.119 (0.077, 0.226) 0.037 (0.019, 0.066) 0.037 (0.017, 0.065)
-++- graduation 0 240 233 307 311
futility 0 0 0 0 0
max_n 0 1 6 7 12
n 9 (5, 13) 6 (2, 12) 6 (2, 12) 6 (2, 11) 5 (2, 11)
n_unique 8 (4, 13) 6 (2, 11) 6 (2, 11) 5 (2, 11) 5 (1, 10)
post_p NA (NA, NA) 0.35 (0.11, 0.59) 0.34 (0.13, 0.63) 0.83 (0.57, 0.97) 0.82 (0.55, 0.96)
rate 0.116 (0.07, 0.197) 0.122 (0.069, 0.253) 0.118 (0.066, 0.221) 0.037 (0.013, 0.077) 0.037 (0.012, 0.08)
-+++ graduation 0 254 253 313 315
futility 0 0 0 0 0
max_n 0 1 6 7 12
n 9 (5, 14) 6 (2, 11) 7 (2, 12) 6 (2, 11) 6 (2, 11)
n_unique 8 (4, 13) 5 (2, 11) 6 (2, 11) 5 (1, 10) 5 (2, 10)
post_p NA (NA, NA) 0.34 (0.14, 0.63) 0.34 (0.15, 0.6) 0.8 (0.54, 0.95) 0.81 (0.55, 0.97)
rate 0.114 (0.063, 0.191) 0.121 (0.066, 0.256) 0.117 (0.068, 0.229) 0.039 (0.015, 0.078) 0.036 (0.012, 0.076)
+— graduation 0 6 9 13 19
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 12 (8, 17) 12 (8, 17) 12 (8, 16) 12 (7, 17) 12 (8, 17)
n_unique 10 (6, 15) 11 (7, 16) 11 (7, 15) 11 (7, 15) 11 (7, 15)
post_p NA (NA, NA) 0.5 (0.18, 0.84) 0.48 (0.17, 0.84) 0.5 (0.18, 0.82) 0.52 (0.19, 0.81)
rate 0.114 (0.074, 0.18) 0.114 (0.072, 0.176) 0.118 (0.076, 0.18) 0.113 (0.075, 0.173) 0.112 (0.077, 0.172)
+–+ graduation 0 66 69 27 32
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 10 (6, 14) 9 (5, 14) 9 (5, 14) 9 (5, 13) 9 (5, 14)
n_unique 9 (5, 13) 8 (5, 13) 8 (4, 13) 9 (5, 13) 8 (4, 13)
post_p NA (NA, NA) 0.48 (0.2, 0.81) 0.48 (0.19, 0.84) 0.48 (0.19, 0.8) 0.5 (0.19, 0.81)
rate 0.116 (0.069, 0.189) 0.117 (0.072, 0.195) 0.119 (0.068, 0.205) 0.119 (0.074, 0.186) 0.112 (0.071, 0.195)
+-+- graduation 0 75 77 39 37
futility 0 0 0 0 0
max_n 0 1 6 8 12
n 10 (6, 15) 9 (4, 14) 9 (5, 13) 10 (5, 14) 10 (5, 14)
n_unique 9 (5, 13) 8 (4, 12) 8 (4, 12) 9 (4, 13) 9 (5, 13)
post_p NA (NA, NA) 0.47 (0.17, 0.79) 0.5 (0.18, 0.78) 0.49 (0.2, 0.82) 0.5 (0.21, 0.83)
rate 0.112 (0.07, 0.184) 0.12 (0.072, 0.198) 0.114 (0.075, 0.195) 0.115 (0.069, 0.18) 0.114 (0.072, 0.182)
+-++ graduation 0 112 122 51 49
futility 0 0 0 0 0
max_n 0 1 6 8 12
n 10 (6, 15) 9 (4, 14) 9 (4, 14) 9 (5, 14) 9 (5, 15)
n_unique 9 (6, 14) 8 (3, 13) 8 (3, 13) 8 (4, 13) 9 (4, 13)
post_p NA (NA, NA) 0.46 (0.16, 0.8) 0.5 (0.19, 0.81) 0.49 (0.19, 0.8) 0.53 (0.21, 0.82)
rate 0.114 (0.069, 0.185) 0.12 (0.073, 0.212) 0.113 (0.072, 0.218) 0.117 (0.069, 0.194) 0.108 (0.07, 0.18)
++– graduation 0 215 199 299 308
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 8 (5, 13) 7 (2, 11) 7 (3, 12) 6 (2, 11) 6 (2, 11)
n_unique 8 (5, 12) 6 (2, 10) 6 (2, 11) 5 (2, 10) 5 (2, 10)
post_p NA (NA, NA) 0.33 (0.13, 0.59) 0.34 (0.14, 0.59) 0.82 (0.55, 0.97) 0.82 (0.57, 0.97)
rate 0.115 (0.068, 0.191) 0.12 (0.069, 0.217) 0.119 (0.063, 0.252) 0.037 (0.013, 0.08) 0.035 (0.013, 0.077)
++-+ graduation 0 232 226 305 313
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 9 (5, 13) 6 (2, 11) 7 (2, 12) 6 (2, 11) 5 (2, 10)
n_unique 8 (4, 12) 5 (2, 10) 6 (2, 11) 5 (2, 10) 5 (2, 10)
post_p NA (NA, NA) 0.33 (0.12, 0.61) 0.34 (0.11, 0.6) 0.8 (0.55, 0.97) 0.81 (0.57, 0.96)
rate 0.112 (0.068, 0.192) 0.124 (0.07, 0.265) 0.115 (0.068, 0.24) 0.037 (0.01, 0.073) 0.035 (0.012, 0.072)
+++- graduation 0 240 233 307 311
futility 0 0 0 0 0
max_n 0 1 6 7 12
n 9 (5, 13) 6 (2, 11) 7 (2, 12) 6 (2, 11) 6 (2, 11)
n_unique 8 (4, 13) 6 (2, 10) 6 (2, 11) 5 (2, 10) 5 (2, 10)
post_p NA (NA, NA) 0.35 (0.15, 0.63) 0.35 (0.12, 0.6) 0.82 (0.57, 0.96) 0.83 (0.53, 0.96)
rate 0.119 (0.069, 0.197) 0.112 (0.065, 0.244) 0.116 (0.068, 0.225) 0.036 (0.014, 0.076) 0.037 (0.014, 0.079)
++++ graduation 0 254 253 313 315
futility 0 0 0 0 0
max_n 0 1 6 7 12
n 9 (5, 14) 6 (2, 12) 6 (2, 12) 6 (2, 11) 6 (2, 11)
n_unique 8 (4, 13) 5 (2, 11) 6 (2, 11) 5 (1, 10) 5 (2, 10)
post_p NA (NA, NA) 0.35 (0.14, 0.6) 0.32 (0.13, 0.59) 0.81 (0.54, 0.96) 0.82 (0.55, 0.97)
rate 0.114 (0.066, 0.19) 0.121 (0.066, 0.235) 0.123 (0.075, 0.244) 0.038 (0.014, 0.075) 0.036 (0.013, 0.074)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 2 13 19
time_stop 5 (5, 5) 10 (4, 33) 27 (12, 34)
n_trt 32 (28, 36) 67 (25, 150) 155 (87, 225)
n_control 34 (24, 44) 70 (31, 265) 203 (82, 275)
post_p 0.9 (0.88, 0.92) 1 (0.92, 1) 1 (0.97, 1)
order 1 (1, 1) 1 (1, 5) 3 (1, 5)
TP53- & AR- count 12 12 140 119
time_stop 10 (8, 14) 14 (10, 16) 16 (10, 33) 17 (10, 30)
n_trt 26 (25, 31) 32 (25, 42) 44 (26, 95) 41 (26, 94)
n_control 24 (22, 38) 38 (30, 48) 47 (25, 104) 48 (26, 97)
post_p 0.9 (0.86, 0.97) 0.94 (0.89, 0.98) 0.97 (0.89, 1) 0.96 (0.89, 1)
order 1 (1, 1.9) 1 (1, 2) 1 (1, 3) 1 (1, 3)
TP53+ count 1 1 25 17
time_stop 9 (9, 9) 8 (8, 8) 11 (8, 24) 21 (10, 32)
n_trt 32 (32, 32) 25 (25, 25) 34 (25, 60) 64 (27, 103)
n_control 23 (23, 23) 15 (15, 15) 32 (22, 72) 71 (33, 113)
post_p 0.92 (0.92, 0.92) 0.99 (0.99, 0.99) 0.98 (0.9, 1) 1 (0.95, 1)
order 1 (1, 1) 1 (1, 1) 1 (1, 3) 2 (1, 3.4)
DRD+ count 291 301
time_stop 24 (14, 34) 23 (14, 33)
n_trt 42 (26, 76) 43 (26, 74)
n_control 51 (25, 82) 47 (25, 79)
post_p 1 (0.98, 1) 1 (0.99, 1)
order 2 (1, 3) 2 (1, 3)
TEfus+ count 18 19
time_stop 12 (10, 20) 20 (11, 30)
n_trt 30 (26, 51) 43 (25, 72)
n_control 30 (24, 52) 49 (25, 85)
post_p 0.99 (0.91, 1) 0.99 (0.97, 1)
order 1.5 (1, 4) 2 (1, 4)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 6 7
time_stop 22 (15, 30) 31 (23, 34)
n_trt 110 (77, 188) 132 (98, 188)
n_control 157 (110, 220) 227 (180, 265)
post_p 0.01 (0.01, 0.2) 0.01 (0, 0.1)
order 3.5 (2.5, 5) 5 (3.6, 6)
TP53- & AR- count 247 233 22 18
time_stop 16 (9, 30) 14 (10, 28) 12 (8, 17) 12 (9, 19)
n_trt 40 (26, 86) 37 (26, 80) 30 (25, 40) 29 (26, 53)
n_control 44 (23, 87) 38 (23, 86) 32 (17, 43) 34 (20, 54)
post_p 0.18 (0.05, 0.28) 0.16 (0.04, 0.27) 0.13 (0.05, 0.23) 0.17 (0.05, 0.26)
order 1 (1, 3) 1 (1, 3) 1 (1, 2) 1 (1, 2)
TP53+ count 74 74 3 2
time_stop 18 (8, 32) 20 (10, 33) 12 (9, 17) 12 (7, 16)
n_trt 54 (26, 87) 58 (27, 101) 28 (27, 42) 34 (27, 41)
n_control 54 (24, 102) 56 (29, 107) 43 (26, 61) 36 (21, 52)
post_p 0.08 (0.02, 0.24) 0.08 (0.01, 0.23) 0.06 (0.02, 0.13) 0.13 (0.13, 0.14)
order 2 (1, 4.7) 2 (1, 4) 1 (1, 1.8) 1 (1, 1)
DRD+ count 214 197
time_stop 21 (14, 32) 22 (16, 32)
n_trt 36 (26, 60) 39 (27, 68)
n_control 43 (24, 70) 47 (28, 77)
post_p 0.1 (0.01, 0.24) 0.09 (0.01, 0.21)
order 2 (1, 4) 2 (1, 4)
TEfus+ count 65 67 1
time_stop 21 (12, 34) 22 (13, 31) 15 (15, 15)
n_trt 44 (27, 77) 49 (29, 76) 25 (25, 25)
n_control 53 (25, 99) 60 (31, 97) 37 (37, 37)
post_p 0.08 (0.01, 0.19) 0.08 (0.01, 0.21) 0.02 (0.02, 0.02)
order 3 (1, 4.6) 3 (1, 5) 1 (1, 1)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Taxel_therapies count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5) 5 (5, 5)
n 12 (10, 13) 0 (0, 1) 5 (3, 7) 2 (1, 4) 1 (0, 2) 1 (0, 2) 0 (0, 0) 1 (0, 2) 2 (0, 3) 2 (1, 3) 2 (2, 2) 0 (0, 1) 2 (2, 2) 0 (0, 1) 1 (0, 2) 0 (0, 0)
post_p 0.6 (0.58, 0.62) NA (NA, NA) 0.57 (0.56, 0.57) 0.57 (0.56, 0.59) 0.6 (0.6, 0.6) 0.53 (0.53, 0.53) NA (NA, NA) 0.5 (0.5, 0.5) 0.62 (0.62, 0.62) 0.53 (0.52, 0.53) 0.51 (0.51, 0.51) 0.53 (0.53, 0.53) 0.57 (0.57, 0.57) 0.54 (0.54, 0.54) 0.58 (0.58, 0.58) NA (NA, NA)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.044 (0.009, 0.078) 0 (0, 0) 0.045 (0.009, 0.08) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.177 (0.177, 0.177) 0 (0, 0) 0.066 (0.013, 0.119) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA)
Carboplatin count 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13
time 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33) 10 (4, 33)
n 14 (6, 39) 4 (0, 10) 13 (4, 29) 8 (1, 18) 3 (2, 8) 3 (1, 8) 2 (1, 7) 2 (1, 3) 4 (1, 13) 3 (1, 7) 3 (0, 7) 3 (1, 9) 2 (0, 5) 2 (1, 4) 2 (0, 8) 3 (0, 5)
post_p 0.7 (0.52, 0.93) 0.59 (0.53, 0.8) 0.59 (0.53, 0.76) 0.64 (0.51, 0.79) 0.59 (0.52, 0.87) 0.69 (0.52, 0.9) 0.59 (0.53, 0.74) 0.55 (0.51, 0.82) 0.62 (0.52, 0.75) 0.65 (0.51, 0.76) 0.56 (0.52, 0.83) 0.56 (0.52, 0.75) 0.53 (0.51, 0.68) 0.64 (0.52, 0.74) 0.62 (0.52, 0.81) 0.63 (0.54, 0.91)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.087 (0.035, 0.127) 0.077 (0, 0.106) 0.095 (0, 0.123) 0.08 (0, 0.123) 0.007 (0, 0.069) 0.02 (0, 0.045) 0 (0, 0.059) 0 (0, 0.074) 0.062 (0, 0.126) 0.031 (0, 0.114) 0.052 (0, 0.13) 0.07 (0, 0.129) 0.038 (0, 0.073) 0 (0, 0.057) 0 (0, 0.058) 0.014 (0, 0.06)
Niraparib count 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19 19
time 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34) 27 (12, 34)
n 36 (16, 59) 5 (2, 10) 26 (12, 32) 14 (7, 23) 6 (2, 14) 6 (2, 12) 3 (0, 8) 3 (1, 6) 9 (3, 12) 5 (0, 8) 9 (2, 14) 6 (0, 9) 3 (1, 8) 3 (1, 6) 5 (1, 9) 4 (2, 8)
post_p 0.65 (0.54, 0.87) 0.72 (0.54, 0.8) 0.62 (0.55, 0.86) 0.69 (0.55, 0.88) 0.88 (0.55, 0.97) 0.86 (0.62, 0.99) 0.76 (0.55, 0.88) 0.65 (0.56, 0.9) 0.6 (0.51, 0.85) 0.62 (0.53, 0.82) 0.57 (0.51, 0.67) 0.64 (0.54, 0.8) 0.74 (0.56, 0.91) 0.65 (0.58, 0.83) 0.72 (0.57, 0.93) 0.75 (0.58, 0.92)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.103 (0.072, 0.122) 0.079 (0.048, 0.171) 0.093 (0.072, 0.118) 0.095 (0.078, 0.11) 0.042 (0, 0.059) 0.026 (0, 0.046) 0.04 (0, 0.052) 0.042 (0, 0.066) 0.093 (0.048, 0.13) 0.094 (0.072, 0.122) 0.106 (0.063, 0.132) 0.086 (0.055, 0.119) 0.033 (0, 0.061) 0.025 (0, 0.05) 0.037 (0, 0.065) 0.018 (0, 0.048)
TP53- & AR- Hormone_therapies count 12 12 12 12
time 10 (8, 14) 10 (8, 14) 10 (8, 14) 10 (8, 14)
n 19 (15, 22) 3 (2, 5) 2 (1, 4) 4 (1, 5)
post_p 0.82 (0.75, 0.93) 0.59 (0.53, 0.72) 0.54 (0.52, 0.63) 0.58 (0.52, 0.69)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.079 (0.055, 0.097) 0 (0, 0.174) 0 (0, 0.043) 0.056 (0, 0.113)
Taxel_therapies count 12 12 12 12
time 14 (10, 16) 14 (10, 16) 14 (10, 16) 14 (10, 16)
n 20 (18, 26) 4 (1, 6) 4 (2, 9) 4 (1, 6)
post_p 0.85 (0.76, 0.97) 0.58 (0.52, 0.75) 0.56 (0.5, 0.82) 0.56 (0.54, 0.75)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.071 (0.044, 0.101) 0.081 (0, 0.112) 0.05 (0, 0.134) 0.059 (0, 0.089)
Carboplatin count 140 140 140 140
time 16 (10, 33) 16 (10, 33) 16 (10, 33) 16 (10, 33)
n 28 (17, 59) 5 (2, 13) 5 (2, 15) 5 (2, 12)
post_p 0.78 (0.71, 0.93) 0.68 (0.52, 0.81) 0.73 (0.55, 0.96) 0.73 (0.55, 0.96)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.086 (0.052, 0.107) 0.071 (0, 0.127) 0.025 (0, 0.056) 0.02 (0, 0.054)
Niraparib count 119 119 119 119
time 17 (10, 30) 17 (10, 30) 17 (10, 30) 17 (10, 30)
n 27 (16, 57) 5 (2, 12) 5 (2, 14) 5 (2, 13)
post_p 0.75 (0.71, 0.88) 0.66 (0.54, 0.84) 0.75 (0.54, 0.95) 0.72 (0.53, 0.94)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.092 (0.061, 0.112) 0.076 (0, 0.143) 0.027 (0, 0.063) 0.027 (0, 0.066)
TP53+ Hormone_therapies count 1 1 1 1 1 1 1 1
time 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9)
n 5 (5, 5) 8 (8, 8) 3 (3, 3) 5 (5, 5) 1 (1, 1) 4 (4, 4) 3 (3, 3) 3 (3, 3)
post_p 0.5 (0.5, 0.5) 0.88 (0.88, 0.88) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) 0.51 (0.51, 0.51) 0.64 (0.64, 0.64) NA (NA, NA) NA (NA, NA)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.098 (0.098, 0.098) 0.068 (0.068, 0.068) 0.107 (0.107, 0.107) 0.044 (0.044, 0.044) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.182 (0.182, 0.182)
Taxel_therapies count 1 1 1 1 1 1 1 1
time 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8)
n 11 (11, 11) 4 (4, 4) 4 (4, 4) 1 (1, 1) 0 (0, 0) 2 (2, 2) 0 (0, 0) 3 (3, 3)
post_p 0.89 (0.89, 0.89) 0.65 (0.65, 0.65) 0.6 (0.6, 0.6) NA (NA, NA) NA (NA, NA) 0.57 (0.57, 0.57) NA (NA, NA) 0.56 (0.56, 0.56)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) 0 (0, 0)
Carboplatin count 25 25 25 25 25 25 25 25
time 11 (8, 24) 11 (8, 24) 11 (8, 24) 11 (8, 24) 11 (8, 24) 11 (8, 24) 11 (8, 24) 11 (8, 24)
n 13 (8, 27) 8 (4, 16) 3 (1, 4) 2 (0, 5) 3 (0, 5) 2 (1, 5) 2 (0, 4) 2 (0, 4)
post_p 0.76 (0.71, 0.87) 0.73 (0.55, 0.84) 0.61 (0.53, 0.75) 0.63 (0.53, 0.73) 0.62 (0.52, 0.83) 0.58 (0.51, 0.71) 0.56 (0.52, 0.65) 0.54 (0.51, 0.85)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.066 (0.023, 0.106) 0.073 (0.035, 0.099) 0 (0, 0.062) 0 (0, 0.071) 0.018 (0, 0.096) 0.067 (0, 0.112) 0 (0, 0.071) 0 (0, 0.078)
Niraparib count 17 17 17 17 17 17 17 17
time 21 (10, 32) 21 (10, 32) 21 (10, 32) 21 (10, 32) 21 (10, 32) 21 (10, 32) 21 (10, 32) 21 (10, 32)
n 23 (10, 32) 13 (3, 25) 4 (1, 11) 4 (2, 8) 4 (1, 10) 4 (1, 8) 3 (1, 9) 3 (1, 10)
post_p 0.8 (0.72, 0.87) 0.73 (0.62, 0.89) 0.73 (0.55, 0.81) 0.7 (0.51, 0.85) 0.6 (0.54, 0.84) 0.66 (0.53, 0.78) 0.6 (0.51, 0.92) 0.71 (0.59, 0.97)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.088 (0.047, 0.104) 0.096 (0.047, 0.113) 0.029 (0, 0.05) 0.02 (0, 0.077) 0.07 (0, 0.108) 0.064 (0, 0.113) 0.023 (0, 0.061) 0.014 (0, 0.054)
DRD+ Carboplatin count 291 291 291 291 291 291 291 291
time 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34)
n 7 (3, 16) 8 (3, 17) 4 (2, 10) 4 (1, 10) 5 (2, 10) 4 (2, 9) 4 (2, 9) 4 (2, 10)
post_p 0.8 (0.58, 0.98) 0.8 (0.59, 0.97) 0.72 (0.55, 0.91) 0.7 (0.53, 0.9) 0.72 (0.53, 0.91) 0.7 (0.53, 0.9) 0.72 (0.53, 0.91) 0.71 (0.53, 0.92)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.031 (0, 0.063) 0.034 (0, 0.062) 0.03 (0, 0.071) 0.03 (0, 0.064) 0.03 (0, 0.074) 0.03 (0, 0.071) 0.028 (0, 0.069) 0.029 (0, 0.073)
Niraparib count 301 301 301 301 301 301 301 301
time 23 (14, 33) 23 (14, 33) 23 (14, 33) 23 (14, 33) 23 (14, 33) 23 (14, 33) 23 (14, 33) 23 (14, 33)
n 8 (3, 15) 8 (3, 15) 4 (1, 10) 5 (2, 9) 5 (2, 9) 4 (2, 9) 5 (2, 9) 4 (2, 9)
post_p 0.82 (0.59, 0.96) 0.8 (0.6, 0.97) 0.7 (0.54, 0.9) 0.7 (0.54, 0.92) 0.73 (0.55, 0.9) 0.72 (0.54, 0.89) 0.72 (0.54, 0.9) 0.71 (0.53, 0.9)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.032 (0, 0.058) 0.033 (0, 0.058) 0.031 (0, 0.066) 0.029 (0, 0.069) 0.029 (0, 0.065) 0.029 (0, 0.071) 0.029 (0, 0.064) 0.027 (0, 0.071)
TEfus+ Carboplatin count 18 18 18 18 18 18 18 18
time 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20) 12 (10, 20)
n 4 (3, 9) 9 (5, 14) 4 (2, 8) 2 (1, 5) 3 (2, 7) 3 (0, 6) 3 (0, 4) 3 (1, 5)
post_p 0.63 (0.53, 0.74) 0.77 (0.63, 0.81) 0.64 (0.55, 0.8) 0.57 (0.53, 0.65) 0.63 (0.53, 0.79) 0.62 (0.55, 0.79) 0.61 (0.51, 0.79) 0.58 (0.52, 0.79)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.072 (0, 0.128) 0.061 (0.035, 0.104) 0 (0, 0.049) 0 (0, 0.071) 0.076 (0, 0.133) 0.068 (0, 0.135) 0 (0, 0.067) 0 (0, 0.069)
Niraparib count 19 19 19 19 19 19 19 19
time 20 (11, 30) 20 (11, 30) 20 (11, 30) 20 (11, 30) 20 (11, 30) 20 (11, 30) 20 (11, 30) 20 (11, 30)
n 4 (3, 11) 15 (5, 23) 6 (3, 15) 3 (1, 6) 3 (2, 6) 5 (1, 8) 3 (2, 5) 2 (1, 8)
post_p 0.73 (0.55, 0.87) 0.81 (0.67, 0.9) 0.78 (0.58, 0.92) 0.67 (0.54, 0.92) 0.57 (0.52, 0.74) 0.6 (0.51, 0.83) 0.65 (0.55, 0.83) 0.57 (0.53, 0.87)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.077 (0.026, 0.117) 0.074 (0.048, 0.099) 0.027 (0, 0.045) 0.011 (0, 0.038) 0.096 (0.038, 0.134) 0.09 (0, 0.125) 0 (0, 0.039) 0.005 (0, 0.07)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6
time 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30) 22 (15, 30)
n 26 (20, 46) 4 (0, 10) 20 (5, 30) 10 (5, 17) 6 (4, 8) 6 (2, 12) 4 (2, 8) 4 (2, 10) 8 (2, 11) 6 (1, 10) 6 (2, 8) 4 (1, 6) 4 (2, 5) 4 (2, 7) 4 (2, 8) 4 (1, 8)
post_p 0.32 (0.18, 0.45) 0.4 (0.39, 0.47) 0.3 (0.1, 0.38) 0.34 (0.24, 0.42) 0.37 (0.08, 0.44) 0.44 (0.33, 0.48) 0.3 (0.13, 0.38) 0.38 (0.25, 0.44) 0.43 (0.34, 0.46) 0.39 (0.32, 0.42) 0.44 (0.25, 0.46) 0.34 (0.26, 0.4) 0.3 (0.24, 0.38) 0.35 (0.18, 0.45) 0.24 (0.18, 0.45) 0.34 (0.15, 0.43)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.119 (0.108, 0.137) 0.161 (0.102, 0.242) 0.139 (0.128, 0.22) 0.139 (0.114, 0.169) 0.153 (0.088, 0.215) 0.1 (0.067, 0.607) 0.152 (0.115, 0.331) 0.138 (0.094, 0.209) 0.138 (0.107, 0.184) 0.152 (0.097, 0.212) 0.127 (0.11, 0.184) 0.195 (0.141, 0.592) 0.178 (0.123, 0.207) 0.143 (0.091, 0.541) 0.204 (0.07, 1.603) 0.111 (0.102, 0.353)
Taxel_therapies count 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7 7
time 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34) 31 (23, 34)
n 23 (21, 48) 4 (2, 11) 29 (11, 35) 10 (5, 19) 5 (3, 10) 6 (2, 11) 2 (2, 8) 3 (1, 8) 7 (3, 11) 8 (4, 8) 7 (4, 11) 4 (1, 6) 5 (3, 10) 6 (3, 10) 4 (1, 10) 3 (1, 6)
post_p 0.32 (0.09, 0.49) 0.4 (0.34, 0.46) 0.3 (0.18, 0.39) 0.35 (0.2, 0.44) 0.17 (0.09, 0.39) 0.3 (0.22, 0.43) 0.32 (0.23, 0.39) 0.37 (0.17, 0.41) 0.32 (0.18, 0.46) 0.24 (0.15, 0.39) 0.29 (0.16, 0.43) 0.38 (0.2, 0.49) 0.41 (0.14, 0.49) 0.35 (0.3, 0.45) 0.36 (0.28, 0.47) 0.44 (0.29, 0.47)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.131 (0.112, 0.164) 0.146 (0.09, 0.366) 0.139 (0.119, 0.151) 0.154 (0.109, 0.179) 0.162 (0.1, 0.186) 0.122 (0.077, 0.216) 0.181 (0.136, 0.543) 0.157 (0.106, 0.496) 0.155 (0.107, 0.468) 0.169 (0.113, 0.347) 0.128 (0.084, 0.154) 0.26 (0.118, 0.445) 0.113 (0.082, 0.301) 0.099 (0.084, 0.21) 0.133 (0.095, 1.155) 0.094 (0.077, 0.148)
TP53- & AR- Hormone_therapies count 247 247 247 247
time 16 (9, 30) 16 (9, 30) 16 (9, 30) 16 (9, 30)
n 24 (15, 53) 5 (2, 12) 5 (2, 11) 5 (2, 11)
post_p 0.33 (0.13, 0.47) 0.42 (0.22, 0.49) 0.37 (0.15, 0.47) 0.38 (0.15, 0.47)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.126 (0.103, 0.171) 0.146 (0.094, 0.282) 0.13 (0.077, 0.259) 0.128 (0.075, 0.33)
Taxel_therapies count 233 233 233 233
time 14 (10, 28) 14 (10, 28) 14 (10, 28) 14 (10, 28)
n 23 (15, 50) 5 (2, 11) 5 (2, 11) 5 (2, 10)
post_p 0.3 (0.11, 0.46) 0.41 (0.23, 0.48) 0.4 (0.15, 0.47) 0.4 (0.22, 0.48)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.128 (0.105, 0.174) 0.158 (0.101, 0.29) 0.135 (0.075, 0.272) 0.133 (0.074, 0.311)
Carboplatin count 22 22 22 22
time 12 (8, 17) 12 (8, 17) 12 (8, 17) 12 (8, 17)
n 18 (14, 26) 4 (0, 6) 4 (1, 7) 4 (2, 8)
post_p 0.25 (0.13, 0.42) 0.37 (0.16, 0.47) 0.46 (0.38, 0.5) 0.4 (0.3, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.141 (0.114, 0.172) 0.208 (0.094, 0.474) 0.085 (0.003, 0.166) 0.113 (0.064, 0.21)
Niraparib count 18 18 18 18
time 12 (9, 19) 12 (9, 19) 12 (9, 19) 12 (9, 19)
n 19 (14, 33) 5 (3, 7) 4 (1, 7) 4 (1, 9)
post_p 0.31 (0.13, 0.41) 0.39 (0.25, 0.47) 0.45 (0.43, 0.5) 0.43 (0.36, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.147 (0.115, 0.196) 0.183 (0.108, 0.34) 0.117 (0.066, 0.202) 0.123 (0.082, 0.358)
TP53+ Hormone_therapies count 74 74 74 74 74 74 74 74
time 18 (8, 32) 18 (8, 32) 18 (8, 32) 18 (8, 32) 18 (8, 32) 18 (8, 32) 18 (8, 32) 18 (8, 32)
n 16 (8, 32) 10 (5, 23) 4 (1, 8) 3 (1, 7) 5 (1, 9) 4 (0, 9) 3 (1, 7) 3 (1, 7)
post_p 0.34 (0.15, 0.48) 0.37 (0.14, 0.47) 0.37 (0.25, 0.48) 0.39 (0.21, 0.48) 0.41 (0.23, 0.49) 0.4 (0.27, 0.49) 0.41 (0.25, 0.48) 0.4 (0.22, 0.49)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.138 (0.097, 0.179) 0.14 (0.102, 0.235) 0.133 (0.079, 0.366) 0.14 (0.077, 0.484) 0.147 (0.09, 0.291) 0.16 (0.101, 0.448) 0.142 (0.078, 0.317) 0.126 (0.071, 0.397)
Taxel_therapies count 74 74 74 74 74 74 74 74
time 20 (10, 33) 20 (10, 33) 20 (10, 33) 20 (10, 33) 20 (10, 33) 20 (10, 33) 20 (10, 33) 20 (10, 33)
n 20 (9, 34) 12 (5, 23) 4 (1, 8) 3 (1, 9) 5 (2, 11) 5 (1, 10) 4 (1, 8) 4 (1, 8)
post_p 0.33 (0.08, 0.48) 0.34 (0.18, 0.48) 0.38 (0.21, 0.48) 0.4 (0.19, 0.46) 0.36 (0.2, 0.48) 0.4 (0.23, 0.48) 0.37 (0.24, 0.46) 0.4 (0.19, 0.48)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.134 (0.103, 0.191) 0.132 (0.105, 0.215) 0.148 (0.079, 0.348) 0.131 (0.069, 0.43) 0.167 (0.11, 0.313) 0.157 (0.102, 0.356) 0.133 (0.068, 0.291) 0.129 (0.076, 0.225)
Carboplatin count 3 3 3 3 3 3 3 3
time 12 (9, 17) 12 (9, 17) 12 (9, 17) 12 (9, 17) 12 (9, 17) 12 (9, 17) 12 (9, 17) 12 (9, 17)
n 11 (10, 14) 7 (4, 13) 3 (1, 5) 3 (1, 5) 2 (1, 4) 3 (1, 3) 2 (1, 2) 0 (0, 3)
post_p 0.36 (0.19, 0.44) 0.16 (0.11, 0.43) 0.46 (0.45, 0.48) 0.44 (0.38, 0.47) 0.46 (0.38, 0.49) 0.39 (0.34, 0.46) 0.42 (0.4, 0.42) 0.49 (0.49, 0.49)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.166 (0.14, 0.209) 0.205 (0.086, 0.274) 0.116 (0.062, 0.177) 0.075 (0.069, 0.707) 0.182 (0.036, 0.21) 0.297 (0.242, 0.412) 0.202 (0.105, 4.715) 0.242 (0.242, 0.242)
Niraparib count 2 2 2 2 2 2 2 2
time 12 (7, 16) 12 (7, 16) 12 (7, 16) 12 (7, 16) 12 (7, 16) 12 (7, 16) 12 (7, 16) 12 (7, 16)
n 12 (9, 16) 8 (6, 10) 0 (0, 1) 4 (3, 5) 4 (3, 5) 2 (1, 2) 2 (0, 3) 2 (1, 3)
post_p 0.3 (0.25, 0.34) 0.35 (0.27, 0.43) 0.48 (0.48, 0.48) 0.49 (0.49, 0.5) 0.43 (0.42, 0.43) 0.46 (0.43, 0.48) 0.46 (0.46, 0.46) 0.42 (0.38, 0.45)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.142 (0.137, 0.147) 0.132 (0.117, 0.147) 0 (0, 0) 0.084 (0.06, 0.108) 0.202 (0.13, 0.273) 0.392 (0.161, 0.622) 0.076 (0.076, 0.076) 0.165 (0.099, 0.231)
DRD+ Hormone_therapies count 214 214 214 214 214 214 214 214
time 21 (14, 32) 21 (14, 32) 21 (14, 32) 21 (14, 32) 21 (14, 32) 21 (14, 32) 21 (14, 32) 21 (14, 32)
n 6 (2, 12) 6 (3, 12) 4 (1, 8) 4 (1, 8) 5 (2, 9) 4 (2, 8) 4 (2, 8) 4 (2, 8)
post_p 0.33 (0.13, 0.47) 0.34 (0.14, 0.47) 0.37 (0.18, 0.48) 0.39 (0.2, 0.48) 0.36 (0.17, 0.48) 0.38 (0.18, 0.46) 0.38 (0.18, 0.48) 0.4 (0.21, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.122 (0.081, 0.241) 0.127 (0.078, 0.258) 0.144 (0.075, 0.357) 0.139 (0.071, 0.314) 0.136 (0.073, 0.382) 0.153 (0.073, 0.312) 0.13 (0.073, 0.324) 0.136 (0.076, 0.305)
Taxel_therapies count 197 197 197 197 197 197 197 197
time 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32) 22 (16, 32)
n 6 (3, 13) 6 (3, 12) 5 (2, 9) 5 (2, 9) 5 (2, 9) 4 (2, 9) 5 (2, 9) 4 (2, 8)
post_p 0.33 (0.1, 0.46) 0.32 (0.13, 0.47) 0.36 (0.18, 0.48) 0.38 (0.2, 0.48) 0.38 (0.19, 0.47) 0.38 (0.17, 0.48) 0.37 (0.18, 0.46) 0.37 (0.16, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.123 (0.079, 0.229) 0.124 (0.078, 0.272) 0.137 (0.078, 0.269) 0.135 (0.076, 0.288) 0.125 (0.074, 0.343) 0.133 (0.077, 0.313) 0.133 (0.084, 0.294) 0.125 (0.078, 0.328)
TEfus+ Hormone_therapies count 65 65 65 65 65 65 65 65
time 21 (12, 34) 21 (12, 34) 21 (12, 34) 21 (12, 34) 21 (12, 34) 21 (12, 34) 21 (12, 34) 21 (12, 34)
n 5 (2, 12) 13 (7, 23) 5 (2, 12) 3 (1, 8) 6 (3, 10) 5 (1, 11) 4 (1, 7) 4 (1, 8)
post_p 0.36 (0.18, 0.48) 0.34 (0.15, 0.47) 0.33 (0.12, 0.44) 0.38 (0.19, 0.46) 0.41 (0.15, 0.49) 0.39 (0.22, 0.48) 0.34 (0.12, 0.48) 0.42 (0.23, 0.49)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.163 (0.103, 0.309) 0.137 (0.103, 0.205) 0.134 (0.079, 0.292) 0.13 (0.081, 0.286) 0.145 (0.1, 0.32) 0.153 (0.095, 0.257) 0.172 (0.073, 0.481) 0.119 (0.074, 0.255)
Taxel_therapies count 67 67 67 67 67 67 67 67
time 22 (13, 31) 22 (13, 31) 22 (13, 31) 22 (13, 31) 22 (13, 31) 22 (13, 31) 22 (13, 31) 22 (13, 31)
n 5 (2, 12) 13 (8, 22) 6 (2, 10) 4 (1, 8) 5 (2, 9) 5 (2, 8) 4 (1, 7) 4 (2, 8)
post_p 0.37 (0.19, 0.5) 0.35 (0.1, 0.47) 0.31 (0.16, 0.47) 0.38 (0.14, 0.47) 0.42 (0.2, 0.48) 0.41 (0.16, 0.49) 0.38 (0.2, 0.48) 0.38 (0.17, 0.48)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.152 (0.098, 0.296) 0.138 (0.102, 0.194) 0.135 (0.078, 0.342) 0.138 (0.068, 0.465) 0.15 (0.097, 0.329) 0.157 (0.095, 0.361) 0.117 (0.063, 0.246) 0.119 (0.074, 0.287)
Niraparib count 1 1 1 1 1 1 1 1
time 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15)
n 1 (1, 1) 6 (6, 6) 0 (0, 0) 3 (3, 3) 6 (6, 6) 5 (5, 5) 1 (1, 1) 3 (3, 3)
post_p 0.46 (0.46, 0.46) 0.48 (0.48, 0.48) NA (NA, NA) 0.4 (0.4, 0.4) 0.17 (0.17, 0.17) 0.13 (0.13, 0.13) 0.37 (0.37, 0.37) 0.48 (0.48, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.151 (0.151, 0.151) 0.118 (0.118, 0.118) NA (NA, NA) 0.151 (0.151, 0.151) 0.223 (0.223, 0.223) 0.361 (0.361, 0.361) 13.589 (13.589, 13.589) 0.041 (0.041, 0.041)